McPherson is located near the geographic center of Kansas and of the contiguous United States. Interstate 135 intersects U.S. Highway 56 at McPherson; and Interstate 70 is just 35 miles north via I-135.
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| Highways Serving the Community | ||
| Highway | Direction | Distance |
| I-135 | N/S | 0 |
| U.S. 81 | N/S | 0 |
| U.S. 56 | E/W | 0 |
| I-70 | E/W | 30 miles |
| U.S. 50 | E/W | 30 miles |
| Highway Distance to Major Cities (miles) | |
| Chicago | 700 |
| Dallas | 430 |
| Denver | 450 |
| Kansas City | 183 |
| Los Angeles | 1,500 |
| Minneapolis | 670 |
| New York | 1,500 |
| Railroads Serving the Community |
| K & O Railroad (short line) |
| Union Pacific (main line via K & O Railroad)* |
| Burlington Northern Santa Fe (main line via K & O Railroad)* |
| *cross-line switching available |
| Time in Transit | |||
| City | Truck (days) | Rail (days) | |
| Atlanta | 2 1/4 | 5 | |
| Chicago | 1 1/4 | 2 | |
| Dallas | 1 | 2 | |
| Denver | 1 | 1 | |
| Kansas City | 1/2 | 1 | |
| Los Angeles | 3 | 3 | |
| Minneapolis | 1 1/4 | 5 | |
| New York | 3 | 4 | |
| St. Louis | 1 | 3 | |
| Seattle | 3 1/2 | 5 | |
McPherson Airport serves a variety of needs in the area including business and personal travel, medical transport, military training, and sport aviation. An active flight training program brings aviation to life for area residents as well as Central Christian College aviation students.

| McPherson City/County Airport | |
| Runway | |
| Type | Concrete |
| Length | 5,550 ft |
| Width | 100 ft |
| Lights & Weather Info | |
| Runway | |
| Taxiway | |
| Beacon | |
| Runway End Indicator (REIL) | |
| Precision Approach Path Indicators (PAPI) | |
| Automatic Weather Observation System (AWOS) | |
| Fuel | |
| Autogas | |
| 100 LL Aircraft Fuel | |
| Jet Fuel | |
| Airport Services | |
| Charter Service | |
| Car Rental | |
| Nearest Commercial Airports (miles) | |
| Wichita | 55 |
| Salina | 30 |